A recent dermatology consensus study from Northwestern Medicine identified the skincare ingredients with the strongest clinical evidence — offering clarity in a market crowded with claims. After surveying 80 board-certified dermatologists from 43 medical institutions, the study highlighted three top-performing, evidence-based ingredients for improving wrinkles, dark spots, texture, and radiance: Vitamin C, Retinol, and Niacinamide. The findings were published in the Journal of the American Academy of Dermatology in “Dermatologist-Recommended Skincare Ingredients: A Delphi Consensus Study”

Niacinamide is a multi-benefit ingredient widely recommended by dermatologists. It helps regulate sebum production, minimize visible pores, reduce acne breakouts, and calm redness through its strong anti-inflammatory properties. Niacinamide also reinforces the skin barrier and enhances antioxidant defenses (Draelos et al., 2021), making it a good choice for maintaining long‑term skin health.

Retinol a derivative of Vitamin A, remains one of the most studied and effective anti-aging ingredients. Clinical trials demonstrate that retinol accelerates cell turnover, stimulates collagen synthesis, and improves signs of aging, including fine wrinkles, firmness, and texture refinement (Kafi et al., 2007).

Vitamin C (ascorbic acid) is celebrated for its brightening power and antioxidant protection. Topical Vitamin C supports collagen production, reduces hyperpigmentation, and enhances overall skin radiance. Research shows that stabilized Vitamin C formulations visibly improve uneven tone and environmental damage (Pullar et al., 2021).

By choosing dermatologist-recommended, clinically proven ingredients — such as Vitamin C, Retinol, and Niacinamide — consumers can build a skincare routine that is results-driven, evidence-based, and optimized for long-term skin health.

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Flyup is a beauty brand specializing in wholesale medical-grade makeup and skincare products to pharmacies, clinics and salons around the world. Our products are recommended by dermatologists and professionals.

• “Quality is our culture”Our main ingredients are imported from FRANCE, GERMANY and SWISS. We also have the ISO22716 GMP certificated. 
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